Karen Plankton

Karen is one of the two main antagonists from the show SpongeBob SquarePants, along with her husband Plankton. She is a waterproof supercomputer who lives in the Chum Bucket laboratory. She supplies Plankton with evil plans to steal the Krabby Patty formula. Karen and Plankton both debut in the episode "Plankton!" from season one.

Trivia
In newer episodes of SpongeBob SquarePants, her screen is smaller, and on wheels.